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Known history or presence of severe acute or chronic liver disease (compensated or decompensated), known cholelithiasis or cholecystitis or bile duct disease, acute or chronic pancreatitis (or medication associated with severe pancreatitis, such as valproate) or severe gastrointestinal dysmotility syndrome, including functional disorders such as severe irritable bowel syndrome

28 Other Approaches to CVD Risk Reduction Risk reduction for CVD among patients with T2DM is achieved by targeting modifiable risk factors such as high blood pressure, high cholesterol, hyperglycemia, smoking, obesity, chronic kidney disease, and albuminuria (Figure 2)

Bin Zhong, orcid.org/0009-0006-9197-3626 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

observed that in T2DM patients (mean age: 64.9 years) treated with subcutaneous semaglutide, reductions in the SMI were smaller than those in the fat mass index (FMI) [56], and the findings suggest a preservation of muscle strength and muscle quality

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