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With age, expression of antioxidant enzymes and NADPH production in GCs decreases, resulting in a lower capacity to neutralize ROS

As expected, GSR tends to be localized in regions of the cell where a high electron flux is located [12]

As noted above, the mid-region residues (S19 Cagri- P25 Cagri ) form the prototypical bypass motif that was observed for rAmy/San385, constrained by conserved intramolecular hydrogen bonds between the backbone of L16 Cagri /F23 Cagri and S20 Cagri , and the backbone of P25 Cagri and N21 Cagri (Fig

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The animals were maintained under standard housing conditions at 22 2 C with 12/12-h light/dark cycles

Add solvent slowly to the vial wall and gently swirl until fully dissolved do not vortex