Increases in levels of the L-carnitine metabolites, butyrylcarnitine (ratio: 7.7) and O-acetylcarnitine (ratio: 14.0), and a decrease in the LC/ALC ratio were observed (Table 2)
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Treatment should continue only if there is a clinically meaningful response (for example, HbA1c reduction 11 mmol/mol and weight loss 3% at around 6 months)
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Second, most clinical trials assessing GLP-1 receptor agonists in liver diseases have relatively short follow-up periods, resulting in limited evidence regarding long-term hepatic outcomes
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