We're always worried about weight regain, and it is closely tied to the hunger returning
According to NICE guidance (NG129) , management focuses on inducing and maintaining remission, preventing complications, and optimising nutritional status
Weight regain commonly occurs if treatment is discontinued without maintained lifestyle modifications, emphasising the importance of sustainable behavioural changes
There is a randomized controlled phase 2 study with the objective to explore the use of TZP as a treatment for MAFLD, providing strong evidence [NCT04166773]
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This risk is heightened in vulnerable populations, including older adults, those with pre-existing CKD, and patients taking medications that affect fluid balance or renal haemodynamics