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Inhibition of glutaminolysis with the glutamine analogue 6-Diazo-5-oxo-L-norleucine (DON) reduces immune-induced and autoimmune Tfh cellular and humoral responses, selectively targeting pathogenic auto-reactive immune cells while preserving the ability of Tfh to generate protective responses against pathogens (55)

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ClinicalTrials.gov (2013)

Kluijtmans LAJ, van den Heuvel LPWJ, Boers GHJ, Frosst P, Stevens EMB, van Oost BA, den Heijer M, Trijbels FJM, Rozen R, and Blom HJ (1996)