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Reduced physical activity
Alterations in the normal function of excitatory amino acid carrier 1 affect cysteine transport and GSH synthesis impairing zinc homeostasis (the thiol group of GSH can function as a principal Zn 2+ chelator for the maintenance of Zn 2+ homeostasis in neurons) and oxidative stress, enhancing susceptibility to ischemia-induced neuronal cell death in the hippocampus (162164)
Systemic effects like headache occur in approximately 1015% of patients but typically resolve within the first month of therapy
Weight loss then gradually slows and may plateau after a year or so on the medication
Current Zepbound labeling says the majority of nausea, vomiting, and diarrhea events occurred during dose escalation and decreased over time
GLP-1 drugs are also complex biological medications that require specialised manufacturing processes
