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Urchins are dioecious organisms and are of high commercial value due to their edible gonads, which are rich in high-quality protein and essential nutrients, such as amino acids, polysaccharides, lipids, vitamins and microminerals 16,17

HCT-8 Cas9 and HCT-8 SQLE -KO cell lines were generated for this study

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Peripheral vascular disease (PVD) occurs when narrowed blood vessels do not provide enough blood supply to muscles when needed