semaglutide and kidney issues does affect function Notable Articles of 2024: FLOW trial In patients with type 2 diabetes chronic disease, weekly Diabetes Distilled: Keeping kidneys FLOWing

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REDEFINE 2, in adults with overweight or obesity and type 2 diabetes, reported a 13.7% mean reduction at 68 weeks versus 3.4% on placebo (Lingvay et al., 2025)

And if a patient meets their goalsloses weight, improves blood sugar, blood pressure, or cholesterolwe may even de-escalate therapy by lowering the semaglutide dose or switching to liraglutide to prevent excess weight loss, which can come at the expense of muscle mass. Overall, switching works best when its intentional and coordinated with your physician

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Ca 2+ -mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak