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The FDA's guidance on compounded drug products notes that compounding is appropriate when a specific patient's clinical need cannot be met by a commercially available product, but it should not be used to circumvent the drug approval process [2]

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Although no specific therapeutic applications in clinical trials have been found for let-7i-5p, miR-146b-5p, and miR-185-5p, these miRNAs have been identified as targets for mitigating the adverse effects of macrophage antigen presentation (Deng et al., 2022), suggesting they may play a role in modulating inflammatory responses