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Traditional calorie restriction in this demographic typically yields 5 to 8 percent weight loss over a year with high regain rates

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Readers should weigh the comparator choices (the paper compares the conjugate favorably against semaglutide, a Novo product, and against a tirzepatide-equivalent backbone, a Lilly product) in light of these affiliations

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10.3389/fphar.2021.794997 Front Pharmacol

Although Semaglutide is a powerful drug for diabetes and weight loss treatment, it may cause temporary menstrual irregularities in some women