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F.et al (2012)

Protein aldehydes derived from LPO including 4-hydroxy-2-nonenal (4-HNE) which is formed during oxidative stress

This review summarizes the mechanism of Hcy-induced endothelial injury and the treatment methods to alleviate the Hcy induced endothelial dysfunction, in order to provide new thoughts for the diagnosis and treatment of Hcy-induced endothelial injury and subsequent AS-related diseases

Furthermore, the GCLC floxed X CaMKII-Cre displays neurodegeneration without overexpressing pathology related genes

The detailed results of that late-stage study were not published as a full peer-reviewed clinical paper, which limits independent appraisal

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