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Semaglutide is contraindicated in individuals with: Individuals with a personal or family history of medullary thyroid carcinoma

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More research is needed to understand the effect of other agonists, as cancer research is lacking

Others want to avoid hormonal manipulation entirely

15 A registry-based cohort and self-controlled case series study of 38,454 patients examined the effect of GLP-1 receptor agonists on the risk of alcohol-related events (alcohol-related hospitalizations, use of medications for AUD, and use of medications for alcohol withdrawal)

Several biomarkers deserve attention throughout the protocol