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Statements Author contributions FL: Writing original draft

It is a natural feedback loop that has kept humans from overeating for millennia

The combination of cagrilintide and retatrutide is not a shortcut

Results observed in one study or experimental model should not be expected in every research setting

In contrast, anorexigenic intestinal peptides as peptide YY (PYY), pancreatic polypeptide (PP), GLP-1, oxyntomodulin and cholecystokinin are low during the fasting period, and their level increases after a meal, and some of them are released proportionally to the amount of calories ingested (Reviewed in [127])

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