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When properly prescribed and monitored, patients achieve sustainable results that diet and exercise alone couldn't deliver

So that's sort of a marker of muscle strain

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Brain Res Bull 2003

During training, a rat started at one of four starting points (North, South, East, West) and was allowed to swim until it located the platform or until 60 seconds had elapsed

Some studies indicate that aligning eating windows with circadian rhythms could affect hormone responses, but this area requires further investigation before specific recommendations can be made