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Industry analysts expect the first generic approvals could arrive by summer 2026, potentially making Canada one of the first major Western jurisdictions with generic semaglutide access ahead of the United States and European Union
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W e cannot conceive of an educational philosophy which does not bring together these two extremes, these two poles of rationality
N Engl J Med 392:427437 le Roux CW, Astrup A, Fujioka K et al (2017) 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial
Traditional calorie restriction can trigger metabolic adaptations that slow weight loss over time, which is why many people struggle to maintain results without broader support
The SURMOUNT-1 trial (Jastreboff et al., NEJM 2022) is the landmark efficacy data: tirzepatide at 15mg weekly produced 22.5% average body weight reduction over 72 weeks in adults with obesity without diabetes the highest weight reduction ever documented in a pharmaceutical trial
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