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Leukopenia, macrocytosis, and thrombocytopenia occur in young adults with Down syndrome

Such a unique system may allow c-MET to respond differently at low or high HGF concentrations

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TB-500 is studied for structural repair mechanisms: organizing the cellular skeleton (actin), promoting cell movement to injury sites, and stimulating blood vessel formation (angiogenesis)

Results from a phase 1 trial have supported further clinical evaluation with a dose-dependent WL up to 14.5% with AMG133 compared to 1.5% with placebo by day 85 [59]