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These risks in humans are unknown, but retatrutide is contraindicated for individuals with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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However, it was not until 2015 that it gained significant attention due to an outbreak in Brazil that was linked to congenital malformations and Guillain-Barr Syndrome 208,209

So, the combination of the two makes up Contrave which works on several different pathways in your brain to curb hunger and cravings

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doi: 10.1056/NEJMoa1607141 40 HolmanRRBethelMAMentzRJThompsonVPLokhnyginaYBuseJBet al