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The immunostaining result showed that the fluorescence intensity of GPX2 (B) and GPX4 (D) in the peroxynitrite group was reduced compared to that of the control group, while it was increased in the peroxynitrite + ebselen group compared with the peroxynitrite-only group

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In this context, caffeine, through its dual role as an ADORA2b antagonist and a direct inhibitor of G6PD (the rate-limiting enzyme of the PPP), emerges as a double-edged metabolic modulator

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