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On the other hand, common neurological diseases, e.g., Alzheimers disease have pronounced both marked sex-dependency (Ferretti et al., 2018) and involvement in the BBB decline (Zenaro et al., 2017)

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NAC also has another important job: it helps regulate glutamate, a key neurotransmitter

Allergy Asthma Immunol Res 14(5):549564

Interestingly, these neuroprotective features have also been shown in humans, where post-menopausal women taking HRT, had fewer and smaller damaged areas after an ischemic event comparing to controls (non-HRT) (Gibson et al., 2006)