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The American Journal of Case Reports, 27, e952158

Participants taking a daily 25mg tablet achieved an average weight loss of 16.6% after 64 weeks, compared with 2.7% in the placebo group

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These benefits have been demonstrated in large, well-designed cardiovascular outcome trials, including: Liraglutide (Victoza) the LEADER trial , which showed a significant reduction in cardiovascular death and all-cause mortality Semaglutide (Ozempic) the SUSTAIN-6 trial , demonstrating fewer major adverse cardiovascular events, particularly stroke Dulaglutide (Trulicity) the REWIND trial , which showed a significant reduction in major cardiovascular events even in people without established cardiovascular disease Tirzepatide (Mounjaro) cardiovascular outcome data from the SURPASS-CVOT programme are emerging, with early results suggesting cardiovascular benefit compared with insulin therapy These cardiovascular effects are a key reason why GLP-1based therapies are now recommended earlier in the treatment pathway for people with type 2 diabetes who have established heart disease or are at high cardiovascular risk

In participants with type 2 diabetes, retatrutide lowered HbA1c by up to 2.02.2% at 3640 weeks across doses, with improvements in fasting glucose, insulin sensitivity, and a high rate of reversion from prediabetes to normoglycemia (up to 72% in relevant cohorts)

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