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Mazdutide reduced liver fat by 80% in participants with elevated baseline levels

Nonetheless, it is unclear whether the protective effect of GLP-1R agonists on fat content stems from weight loss, which, among other things, increases insulin sensitivity and improves glycemia and lipid profile, or from direct activation of the hepatic GLP-1R

GLP-1 has recently been shown to increase hepatic insulin signaling and sensitivity [9]

doi:10.1001/jama.2020.12567 Asai A, Nakagawa K, Higuchi O, Kimura T, Kojima Y, Kariya J,

& Mansel, R