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The standard retatrutide dose schedule follows a once-weekly injection pattern, consistent with how the molecule was studied in clinical trials

Source: Evaluate Pharma, World Obesity Federation, Putnam Analysis Q2, 2025 Unmet Needs and Potential Differentiation Levers Despite extraordinary promise, there are still unmet needs that biopharma companies can target to address: GI Tolerability The most common GI adverse events (nausea, vomiting, and diarrhea) often lead to therapy discontinuation

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Dizziness occurs in some users, particularly during the first weeks

Reducing the population and activity of SRB is the long-term goal