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Upon conjugation with glutathione, the selectivity index of epothilone towards the tumor cell lines was increased by about 5.7 folds, ensuring their higher solubility, facilitating the penetration of the drugs across the plasma membrane via the ATP-Binding Cassette (ABC) proteins ABCC1 that called GSH-S-conjugate pump [6, 41, 53, 78]

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Clinical trial evidence, particularly from the SURPASS studies, demonstrates that tirzepatide provides effective glycemic control while simultaneously addressing multiple metabolic risks, offering an advantage over existing therapies (Jastreboff et al