The body has had 12+ weeks to adapt to amylin signaling
116:109741 Thymosin beta-4 and peptide-mediated cellular signaling pathways Dou Y, Lee A, Zhu L, Morton J, Ladiges W., Aging Pathobiology and Therapeutics , 2020
For Concentrations often range from 1-10 M (micromolar)
At the 12 mg dose, 93% of participants achieved at least 5% weight loss
Side effects for GLP-1s may include nausea, vomiting, stomach pain, upset stomach, dizziness, constipation, feeling bloated, belching, gas, headaches, and fatigue
This results in muscle fatigue, trigger points, muscle knots, and eventually persistent spasms