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No IGF-1 elevation
IGF-1 LR3 remains an agonist of the IGF-1 receptor, but it has very low affinity for IGFBPs, which inhibit IGF-1, making it more potent
Patients do not simply feel "tired"
In summary, the implication of IGF-1 in glucose and lipid metabolism and its derangements when the GH/insulin/IGF-1 axis balance fails is well documented
Hede MS et al
The resulting suspension was separated by centrifugation at 12,000 rpm for 30 min at 4 C, and the protein concentrations was performed as in a previous report [28]
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