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Store the sealed lyophilised vials at -20C, kept dry and protected from light, and hold any reconstituted material at 2-8C

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Data availability The Cryo-EM density maps and associated masks have been deposited in the EMDB under accession number EMD-63371, EMD-63372, EMD-63374, EMD-63375, EMD-63397, EMD-63383, EMD-63385, and EMD-63386, EMD-63565, and EMD-65758

Full model: Adjusted for sex, age, inclusion date, diabetes duration, Charlson Comorbidity Index, any diabetic complications, previous falls, inflammatory bowel disease, ever insulin use, ever glucocorticoid use, hypertension, kidney disease, alcohol, smoking and obesity, and stratified by osteoporosis