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GLP-1R siRNA (SR515617) and negative control scrambled RNA (SR30004) were prepared at 500 pmol in 5 l of RNAse free suspension buffer (SR30005) (OriGene Technologies, Rockville, MD, United States) and infused (the siRNAs) 48 h before SAH induction in the SAH + Ex-4 + GLP-1R siRNA and SAH + Ex-4 + Scr siRNA groups, respectively

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In August 2025, Wegovy was also FDA approved to treat certain patients with a type of liver disease called MASH

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