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They also possessed specific physiological characteristics related to the underlying cause of their sleep apnea, including more severe upper-airway collapsibility, greater breathing control instabilityreferred to as high loop gainand a tendency to wake more easily during airflow obstruction

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Ward and colleagues then expanded on this by showing that a full-length, hen egg lysozyme-specific, human IgG1 MST/HN mAb could reduce the disease burden in mouse models of both experimental autoimmune encephalomyelitis [119] and arthritis [120]

Intracellular metabolite concentrations have to fine-tune the signaling networks governing metabolic pathways independently of the environment to ensure a balance between the availability of nutrients and the cellular capacity to use them effectively