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Hypoxia-preconditioned BMSCs secrete functional paracrine molecules such as VEGF and miR-126, which not only inhibit right ventricular cardiomyocyte apoptosis, alleviate inflammation and fibrosis, but also improve pulmonary vascular remodeling and reduce mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR) ( 4 Factors affecting the efficacy of MSCs therapy for PH The properties and functions of MSCs are influenced by various factors, including donor age, culture techniques, and preservation methods
By day 3 if the patients INR has not budged at all from baseline, perhaps its time to increase the dose
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The complete selection process, including the number of records identified, screened, and excluded with explicit reasons (separated for preclinical and clinical/epidemiological literature), is documented in the PRISMA flow diagram (Figure 1)
