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In the cytosol, N -acetyl transferases create mercapturic acid versions of the xenobiotics which are generally more polar and more water soluble than the parental compound
When the SNACsemaglutide complex reaches the gastric epithelium, the lipophilic SNAC enters the cell membrane, which affects its fluidity, leading to rapid transcellular absorption of semaglutide [14, 28]
Darwesh AM, El-Azab MF, Abo-Gresha NM, El-Sayed NM, Moustafa YM
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