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For subcutaneous use only

Readers can review the FDA's March 2026 announcement directly at FDA.gov

[32] Patients using oral potassium supplements, potassium-sparing diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, or aldosterone antagonists should be monitored for potential additive effects on potassium levels when using formulations containing topical spironolactone, though the risk of clinically significant hyperkalemia from topical application appears to be minimal based on current evidence

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There are gaps in current research, and more studies are needed to fully understand the long-term impact of semaglutide on nerve health