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semaglutide Both metformin and semaglutide frequently cause side effects, especially at the start of treatment or when doses are increased

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Genetic polymorphisms are heritable changes in DNA sequences as consequence of single-nucleotide polymorphisms or stable point mutations that may partially alter enzyme activity, or large deletions in coding sequences resulting in a null phenotype 24,34

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And most patients don't realise that until they've already started both therapies simultaneously