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Its silencing enhances sensitivity to cisplatin-induced DNA damage [116]
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Glutathione and Glutamine Deficiency The lack of glutathione can cause seizures, intellectual disability, loss of coordination, and more, while the lack of glutamine negative influence on immune status, protein metabolism, and disease outcome
Several research teams have targeted GSH synthesis inhibitors as potential therapeutic agents
Citation54 Glutathione peroxidases, particularly GPx1 have also been implicated in the development and prevention of many common and complex diseases, including cancer and cardiovascular disease ( Citation55 8 Conclusion The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) constitute a first line antioxidant defence system which plays a key and fundamental role in the total defense mechanisms and strategies in biological systems
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