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The N terminus (the first 11 residues) that is highly conserved across GIP, GLP-1 and GCG interacts with the lower half of the TMD pocket of the three receptors consisting of conserved residues such as L/Y 1.36b (hydrophobic with K10 P ), Q/Y 1.40b (hydrogen bond with K10 P ), Y 1.43b (stacking with F6 P ), Y 1.47b (hydrogen bond with Q3 P ), Q 3.37b (hydrogen bond with H1 P ), ECL2 (hydrogen bond with S8 P ), R 7.35b (salt bridge with D9 P ), I/L 7.43b (hydrophobic with Aib2 P ) and L 7.43b (hydrophobic with F6 P ) (Figs
GLP-1R agonists exhibit protective and regulatory effects on blood glucose levels but have been linked to the inhibition of tumor cell proliferation in most cancer cases, as seen in vitro and summarized in Table 1 [51, 73]
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doi:10.1007/s40261-015-0368-5 HerxheimerA, Petrie KJ
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