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It is likely that many patients will require intramuscular B12 replacement for the duration of their metformin treatment, although a trial of oral replacement initially may be worthwhile.
Trace minerals include boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, zinc, and others
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A preferred strategy is the delivery of exogenous HGF by gene transfer, with the advantage of less side effects