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Activation of hepatic microsomal glutathione S-transferase of rats by a glutathione depletor, diethylmaleate

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doi: 10.3389/fpsyt.2022.977538 212 LiZQingYCuiGLiMLiuTZengYet al

Erastin is a small molecule that inhibits the cellular import of cystine, a key component of GSH, thus lowering the levels of intracellular GSH 23 (Fig 4A)

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This design is specifically intended to increase bioavailability and ensure more of the nutrient reaches the cells