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The clinical and laboratory characteristics of the study participants are shown in Table 1

The pathogenesis of MTX-induced renal impairment is thought to be mediated by either MTX and its metabolites precipitating in the renal tubules or MTXs direct toxic impact on the renal tubules (Reference Widemann and Adamson6)

The catalytic reaction of nitroxides with peroxyl radicals and its relevance to their cytoprotective properties

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Injectable routes include subcutaneous, intramuscular, and intravenous administration, with subcutaneous injection being most common for chronic therapies

A review of the effects of Capsicum annuum L