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The role of the insulin/IGF system in cancer: lessons learned from clinical trials and the energy balance-cancer link

Because of its structural differences, IGF-1 LR3 shows reduced affinity for certain IGF-binding proteins (IGFBPs) in vitro, enabling researchers to study more sustained receptor engagement and downstream signaling under controlled conditions

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Complementary in silico modeling and AI can integrate these multi-scale data to predict nanocarrier behavior, identify potential hotspots of accumulation or toxicity, and support safer-by-design optimization (247253)

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