Karczewski KJ, Francioli LC, Tiao G, Cummings BB, Alfoldi J, Wang Q, et al
B12 supplements are often used to treat or prevent deficiency, which can lead to symptoms such as fatigue, weakness, constipation, loss of appetite, and megaloblastic anemia
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However, treatment decisions should always be individualized and medically supervised
In gastrointestinal research, a 2017 rat colitis and ischemia-reperfusion study by Duzel and colleagues in World Journal of Gastroenterology reported that a single 10 g/kg topical bath of BPC-157 to blood-deprived colon segments produced near-complete mucosal preservation by day 10, restored vessel-arcade interconnections, and normalized MDA and NO levels relative to saline controls though the abstract does not report numeric % lesion reduction or p-values