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The metabolites showed much lower toxicity compared to the parent compounds [423]

In a clinical study, application of ruxolitinib cream for 28 days significantly decreased the extent and severity of psoriasis lesions compared with placebo, with only mild side effects reported

Following peripheral administration, exenatide has been shown to suppress food intake via vagal-dependent and vagal-independent pathways that result in the direct activation of GLP-1R in the central nervous system

Losartan is an angiotensin II receptor blocker (ARB) that does not directly interact with oestrogen or androgen receptors, making a causal link to gynaecomastia pharmacologically implausible

Alcohol is best avoided during dose titration, as it amplifies GI side effects and affects liver function

That is why metformin carries a very low risk of causing low blood sugar compared to other diabetes medicines