Repeated injection into the same spot causes the subcutaneous fat tissue to thicken and become fibrous, a condition called lipohypertrophy
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If you develop only localized redness or swelling at the injection site that resolves within 48 hours, allergic reaction is unlikely, though your healthcare provider can evaluate your specific situation
Dysregulation of brain IRS-1 contributes to developing brain insulin resistance (BIR), a hallmark of AD and other neurodegenerative diseases (Craft et al
doi: 10.3389/fendo.2021.747888 16 GuoYQiYYangXZhaoLWenSLiuYet al