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Low urinary pH predisposes for uric acid precipitation since the pKa of uric acid is 5.7, therefore the solubility of uric acid decreases with low pH, and thus increasing the risk of kidney stones (44)
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Gastrointestinal side effects may include constipation, biliary disease, bowel obstruction or gastroparesis, among others
Ageing Dev
[12] Gastric acid-suppressing agents (proton-pump inhibitors and H-receptor antagonists) diminish dietary B12 liberation from protein complexes, a pharmacodynamic interaction that can exacerbate underlying deficiency
They are particularly beneficial for older adults and those with conditions that impair B12 absorption
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