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doi:10.1093/clinchem/47.8.1467

Darkening of skin is a relatively common problem

A trained pediatric phlebotomist conducted all blood draw procedures

Genetics plays a role here, and people who have genetically lower IgE levels are less likely to have chronic urticaria.[ref] Mast cells, atrial fibrillation, and cardiac diseases: Researchers estimate that there are ~50,000 mast cells/g of human heart tissue

Vigorous agitation generates shear forces and an air-liquid interface that promote peptide aggregation, and it produces foam that traps material away from the solution

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