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In these cardiovascular safety trials, in secondary or exploratory analyses, GLP-1 receptor agonists were also shown to reduce macro-albuminuria, an accepted surrogate marker for diabetic kidney disease (DKD), a condition that still represents a major unmet medical need

F., & Bindra, R

Available from: Busby MG, Fischer L, da Costa KA, Thompson D, Mar MH, Zeisel SH

127 Further, mice homozygous for the Plin1 deletion exhibit high basal lipolysis and are unresponsive to adrenergic stimulation, confirming that PLIN is actively controls lipolysis 128,129 Taken together, all the evidence supports that white adipose tissue (WAT) lipolysis suppression of insulin also associated with hepatic gluconeogenes, and the mechanisms of IR include complex mediators and metabolic networks

Studies document improvements in fasting plasma glucose, postprandial glucose excursions, and overall glucose time-in-range metrics