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[7] [8] [2] The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer

It then binds to intrinsic factor (IF), a glycoprotein secreted by the parietal cells of the gastric mucosa

There are multiple medical conditions related to vitamin B12 deficiency

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In the U.S., injectable B12 (cyanocobalamin and hydroxocobalamin) is only available with a prescription, as regulated by the FDA