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The locus on chromosome 1 near TMCO1 demonstrated strong external support in the UK Biobank European ancestry dataset, where multiple variants within this region showed highly significant associations with POAG and consistent direction of effect
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Unbound (bioavailable) IGF1 enhances somatic growth
Paired paraffin-embedded tissue and RNA samples were prepared from all patients to allow cross-referencing between histological assessments and qPCR gene expression analysis
Julius, M., Lang, C
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