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(118) demonstrated that NOTCH signaling activation induces transcription of Asb2 and Skp2

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All such effects are observations drawn from preclinical, in-vitro, and animal investigations

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These cells contribute to the permeability and integrity of the BBB through their intimate anatomical relationship (Liebner et al., Every constituent cell of the NVU contributes to the BBBs integrity, and any dysfunction might result in the barrier breakdown, with dramatic consequences such as neuroinflammation and neurodegeneration (Kempuraj et al., 2019)
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