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Moreover, there are several paradigmatic conditions such as Down syndrome, phenylketonuria, and various lipidoses (Scriver et al., 1989) where the metabolic abnormalities are expressed in both neural and peripheral tissues, but the functional consequences are most profound in the central nervous system (CNS)

10.2527/jas.2013-6690 171 LiuG.GuK.WangF.JiaG.ZhaoH.ChenX.et al (2021a)

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Further, it inhibits 4-hydroxynoneal, a molecule produced in the body that negatively impacts cellular growth