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Semaglutide and Weight Loss Also approved as a weight management treatment, semaglutide has demonstrated anti-obesity effects attributed to its appetite suppression
Science 364 , 11791184 (2019)
Clinical studies demonstrate average body weight reductions of 15 to 20 percent over a 72-week period, offering a fresh avenue for long-term weight management in Woburn
Even though it is synthetic, it acts similarly to the hormone GLP-1 naturally produced by the body that is deficient in people with T2D
The reason for the long wait is unclear, but it may be telling that the company that initially developed PT-141 (King Pharmaceuticals) was acquired in 2010 by Pfizer, which famously manufactures Viagra and had a vested interest in keeping PT-141 off the shelves until after Viagras patent expired in 2020
The current evidence is mostly observational, and people with prior cancer were often excluded from the large trials that led to GLP-1 approvals
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