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The SELECT cardiovascular outcomes trial (N=17,604), published in NEJM 2023 (DOI: 10.1056/NEJMoa2307563), demonstrated a 20% reduction in major adverse cardiovascular events (MACE) -- the composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke -- in overweight or obese adults without diabetes

After you eat, your body breaks down the food into glucose (a type of sugar), which enters the bloodstream

During fasting hours, insulin levels fall and the body gradually shifts from using glucose to using fat as its primary energy source

The conservative 1mg starting dose allows assessment of individual tolerance before increasing

Shi M, Liu L, Min X, Mi L, Chai Y, Chen F, et al

How Retatrutide Works Retatrutide acts on three hormone pathways at the same time: GLP-1, GIP, and glucagon